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Doxy-PEP: STI prevention you take after sex
Doxycycline post-exposure prophylaxis (Doxy-PEP) can lower your chance of getting syphilis, chlamydia and gonorrhea. Prescribed online by licensed providers, with judgment-free, LGBTQ+ affirming care.
- LGBTQ+ affirming providers
- 100% online and private
- Discreet shipping
A simple step after sex that helps prevent bacterial STIs
Doxy-PEP means taking a single dose of the antibiotic doxycycline within 72 hours after condomless oral, anal or vaginal sex. Studies have shown it can reduce new syphilis and chlamydia infections by about two-thirds or more, and lower gonorrhea infections as well.
The CDC recommends Doxy-PEP for gay and bisexual men and transgender women who have had at least one bacterial STI in the past 12 months. Your provider will talk with you about whether it fits your sex life and health history.
- Taken only when you need it, after sex rather than every day
- Works alongside your current plan, including PrEP and condoms
- Private and judgment-free: your visit happens online, on your schedule
Getting Doxy-PEP online
- Complete your visitAnswer a short, confidential health questionnaire online.
- Provider reviewA licensed provider reviews your history and answers your questions.
- Delivered to youIf approved, doxycycline is shipped in plain packaging to keep on hand.
Doxy-PEP is one part of sexual health care
- Doxy-PEP does not prevent HIV, mpox or herpes. Keep using PrEP and condoms as part of your plan.
- Regular STI testing every 3 to 6 months is still important. Your provider will explain how to stay on schedule.
- Take doxycycline with a full glass of water and stay upright for 30 minutes afterward.
- Doxycycline can make your skin more sensitive to the sun, so use sunscreen.
Doxy-PEP is not right for everyone. Your provider will review your medications and health history before prescribing.
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Doxy-PEP FAQs
Who is Doxy-PEP for?
It is recommended for gay and bisexual men and transgender women who have had syphilis, chlamydia or gonorrhea in the past year, and may be considered for others at higher risk. Your provider will help you decide.
When do I take it?
As soon as possible after condomless sex, ideally within 24 hours and no later than 72 hours.
Does it replace PrEP or condoms?
No. Doxy-PEP helps prevent some bacterial STIs only. It does not protect against HIV, so keep using PrEP and condoms.
Is my visit private?
Yes. Your visit happens through a secure portal, and orders ship in plain packaging.
Take control of your sexual health
Start a private online visit and a licensed provider will review whether Doxy-PEP is right for you.